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袁生

 

发布日期:2015-07-21  浏览次数:881

袁生,博士,教授,博士生导师,南京师范大学生命科学学院院长,教育部生物科学专业教学指导分委员会委员,中国微生物学会理事, 江苏省微生物学会秘书长,江苏省微生物学精品课程主持人。1997年北京师范大学生物系博士研究生毕业,1998-2001年美国宾州州立大学生物系博士后。1990年以来,先后主持国家自然科学基金5项,国家科技部“十五”科技攻关项目子课题2项,以及其它省部级项目和企业委托项目10多项。在国内外发表论文80余篇,获得国家发明专利10项,参与撰写专著、教材3部, 先后获得省科技进步成果奖、省优秀教学成果奖等奖励。主要研究方向为微生物生长代谢调控研究。在微生物生长代谢调控的分子生物学研究领域:主要从事酵母细 胞增殖、菌丝顶端生长、细胞壁伸长生长的功能基因组学研究。在微生物代谢调控与药物合成研究领域:主要研究和利用微生物特殊和多样化代谢途径,开展微生物 转化合成药物、农药及其中间体的研究。

 

微生物生长代谢调控的分子生物学研究代表作(*通讯作者):

1. Yuan SJ Wu and D Cosgrove (2001). A Fungal Endoglucanase with Plant Wall Extension Activity. Plant Physiol., 127, 324-333.
2. Zhao Q, S. Yuan*, X. Wang, Y. Zhang, H. Zhu, C. Lu (2008). Restoration of mature etiolated cucumber hypocotyl cell wall susceptibility to expansin by pretreatment with fungal pectinases and EGTA in vitro. Plant Physiol. 2008; 147(4):1874-1885.
3. Wang J, S Yuan* and SB Jiang (2006). The Ribosomal Protein L32-2 (RPL32-2) of S. Pombe Exhibits a Novel Extraribosomal Function by Acting As a Potential Transcriptional Regulator. FEBS letters
5801827-1832.
4. Wang G., L. Lu,*, C.-Y. Zhang, A. Singapuri, and S. Yuan (2006). Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans. Protoplasma, 228:159-166.
5. Zhao Q, S Yuan*, Zhang Y, H Zhu, C Dai, F Yang, F Han (2007). Expression, Purification and Characterization of Pectate Lyase A from Aspergillus nidulans in Escherichia coli. World J Microbiol Biotechnol, 23:1057-1064.

 

微生物代谢调控与药物合成研究代表作(*通讯作者):
1. Jiang J.-R., S. Yuan*, J.-F. Ding , S-C Zhu, H.-D. Xu, T. Chen, X.-D Cong, W.-P. Xu, H. Ye, Y-J Dai (2008) Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. Applied Microbiology and Biotechnology, DOI 10.1007/s00253-008-1683-z, on line.
2. Yue H, S Yuan*, X Cong (2007). Biotransformation Of Puerarin Into 3
-Hydrooxypuerarin By Trichoderma harzianum NJ01. Enzyme and Microbial Technology, 40594-597.
3. Dai Y-J, S Yuan*, F Ge, T Chen, S-C Xu, J-P Ni (2006). Microbial Hydroxylation of Imidacloprid for Synthesis of Highly Insecticidal Olefin Imidacloprid. Applied Microbiology and Biotechnology, 71
927-934.
4. Dai Y-J, T Chen, F Ge, Y Huan, S Yuan*, and F Zhu (2007). Enhanced hydroxylation of imidacloprid by Stenotrophomonas maltophilia upon addition of sucrose. Applied Microbiology and Biotechnology, 74, 995-1000.
5. Chen T., Dai Y.-J., Ding J.-F., Yuan S. *, Ni J.-P.(2008) N-demethylation of neonicotinoid insecticide acetamiprid by bacterium Stenotrophomonas maltophilia CGMCC 1.1788. Biodegradation.19(5): 651-658.

 

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